They represent Christendom nowadays. They will have the same fate when Babylon the Great is destroyed. Just like they have spilt a lot of blood over centuries... "Jehovah has a sword; it will be covered with blood. It will be covered with the fat, With the blood of young rams and goats, With the kidney fat of rams. For Jehovah has a sacrifice in Bozʹrah, A great slaughter in the land of Eʹdom." — Isaiah 34:6
And just like them and the rest of Babylon the Great, they will disappear forever: "Her streams will be changed into pitch, And her dust into sulfur, And her land will become like burning pitch. By night or by day it will not be extinguished; Its smoke will keep ascending forever. From generation to generation she will remain devastated; No one will pass through her forever and ever." — Isaiah 34:9, 10.
Compare with:" And right away for the second time they said: “Praise Jah! And the smoke from her goes on ascending forever and ever.” — Revelation 19:3